Rivaroxaban tablets for thrombosis and stroke, let us discuss river OAKSA Ban. What is this drug? River OXA ban. From the name of this drug we can find one of the suffix zaban. Here, XE indicates factor ten A.
The term ban signifies it inhibits the activity of factor tena. So river Oxyban is one of the factor ten A inhibitor and this drug acts as anticoagulant to inhibit the formation of the clot by inhibiting the coagulation cascade.
Since factor tenure plays an important role.
In coagulation pathways, inhibition of this factor results in the decreased coagulation. That’s why riveroxaban can be used in the conditions where there is a formation of abnormal clot which is called as thrombus.
- This thrombus is rich in platelets, coagulation.
- Factors and lipids like cholesterol, where this.
- Drug can reduce the thrombus formation by.
- Inhibiting the clot formation.
Normally, this thrombus is highly pathological. When it is going to be fragmented, it can block the blood vessels. So a small fragment from the thrombus can enter into the blood vessels, where.
Rivaroxaban tablets for thrombosis and stroke
It can block these blood vessels, resulting in systemic embolism. Since these conditions river oxyband can be.
Used to reduce the embolism formation and reduce the risk of sudden stroke in the patients, particularly in the patients with.
Nonvolvular atrial fibrillation, the heart is contracting. At a high rate which increase the.
Clot formation, resulting in the stroke in. The patients as well as it can increase the systemic embolism. In such conditions, river oxyband can be used to reduce the clot formation, thereby to reduce the risk of stroke and embolism.
Similarly, this can be used in the patients who are having the risk of.
Deep bin thrombosis, which may lead to pulmonary embolism. So again in such conditions river oxyband can be used.
See how this drug acts. What are the important precautions, side effects, doses? All these things we will discuss in this . Now let us see how this drug acts. Within the interim of the blood vessels.
Factor tenure plays an important role in clot formation.
This factor ten A actuates another factor protrombin or factor two. Normally, factor two A requires other cofactors like factor five A, phospholipids and calcium. These cofactors and minerals can be combined with the factor ten A, which is.
- Then can interact with the protrombin two, such that it is going to be.
- Converted into factor two A.
- Now, factor two A is a thrombin, which is the active form of the.
- Factor two and this can convert the ender precursor fibrinogen.
- This fibrinogen can be converted into Fibrine.
Meshwork by the factor two E. This meshwork is responsible for formation of dense clot which increase the thrombotic events.
Now, river Oxyban is an anticoagulant. It can act on the factor ten A, thereby can reduce its activity. This results in the decreased clot formation.
Thereby reduce the thrombus formation. In this way, river oxyband can be used as anticoagulant. Now let us the precautions of this drug. Since river Oxyban is one of the.
Anticoagulant, one of the important precaution of.
This drug is that this drug can increase the risk of bleeding within the patients.
- So this drug should be carefully given.
- As this drug reduce the factor two.
- A activity, thereby it reduce the clot formation. So this may result in the increased.
- Risk of bleeding, which is more pronounced.
- With other drugs like aspirin, which is an antiplatelet agent.
Similarly fibrinolytics like Altiplase, Eurokinase, all these drugs can increase the risk of bleeding produced by rivroxaban. So carcinogen should be taken when riveroxaban is combined with antiplatelets and fibrinolytics.
- Similarly, CYP three A four inhibitors like.
- Ketokanazole retinavir, these drugs can inhibit the.
- Metabolism of riveroxaban which increase the levels.
Of this drug, thereby they can increase the risk of bleeding. So again, CYP three A four inhibitors should not be combined with riveroxa ban. Since risk of bleeding is more pronounced with anticoagulants, the patient should be closely.
But in the normal case of bleeding, the rivroxaban may be replaced with an alternative agent to reduce the risk of bleeding. This riveroxaban is highly protein bound, so.
When it is bound to the protein it is not easily excreted, even it is not easily undergo dialysis. So normal drug molecules can easily undergo dialysis, but those molecules which are protein bound are not dialysable.
Thereby, we cannot reverse the risk of bleeding produced by riveroxaban under its toxic levels. And there is no specific antidote is.
Available for this drug. But protromine complex concentrates can somewhat reduce.
- The risk of breeding which is produced by revoxapan.
- Similarly, in the case of any premature.
- Discontinuation of the drug, this drug may.
- Increase the thrombotic events. So risk of thrombosis is more pronounced.
On sudden stopping of the dose, incompleting the therapy. So there is a sense to balance between the risk of bleeding and risk of thrombosis. At high dose it increase the risk of bleeding, but when it is suddenly stopped, it can increase the risk of thrombosis.
So this drug should be carefully given to the patients who are having more.
- Risk for thrombosis under optimal conditions to control the bleeding as a side effect.
- Similarly, this drug should not be given to the pregnant woman as it increase.
- The risk of hemorrhage related with the pregnancy. Now let us see the side effects of this drug.
As we have discussed, breeding is one of the important side effect of this.
Drug, so it can produce some gastrointestinal breeding as well as cranial bleeding. Apart from hemorrhage, it can produce other side effects like abdominal pain, toothache dyspepsia, sinusitis, back pain, fatigue and osteoarthritis. Joint pain can be produced by this drug. How it is given this drug is.
Available as a tablet and a nonvoller atl fibrillation to prevent any thrombotic events. This drug can be given at a.
Dose of 20 mg once daily.
But for the treatment of deep wind thrombosis and pulmonary embolism, this drug can be given at a dose of 15 mg, given twice daily for 21 days. After 21 days, the dose may be.
- Increased to 20 mg given once daily.
- These 20 mg and 15 mg dose.
- Should be given along with evening meal.
- As would reduce the risk of side.
- Effects produced by this drug.
- For prophylax of DVT and pulmonary embolism, this drug can be given at a.
- Dose of ten mg once daily and.
- A therapy can be continued based on prophylaxis. For knee and hip joint replacement, this.
Drug can be given as a prophylactic. So that’s about this drug river Oxyband.
- River Oxyban is one of the anticoagulant.
- It is a factor ten, a inhibitor.
- This drug can reduce the risk of deep bin thrombosis and pulmonary embolism and.
- It can also reduce the risk of stroke and systemic embolism.
That’s why this drug can be given in the patients with nonvolvular atrial fibrillation. To reduce the formation of stroke. Haemorrhage is the main side effect of this drug, but when this drug is.