Crotamiton cream and lotion for scabies, let us discuss about crotamateone. What is this drug, crotamateone? The suffix crote indicates that this drug is a derivative of crotonic acid. And the suffix am indicates it is available as amide. And finally, the suffix tongue indicates it is a topical agent.
So crotamateone is a crotonic acid, amide, which is given by topical root. Then what is the use of this drug? Krotamitan is used for the treatment of scabies, where this drug can reduce the itching and it also reduce the pruritis. So this is one of the drugs which is having the scabicidal action as well as anti p ruritis action. The scabies mites can produce some itching, redness of the skin, which is going to be relieved by cortametone.
This drug is available as a cream as well as a solution. And here this drug acts as counter irritant. So this drug can be applied on the affected area. When it is applied on the skin, it can produce a counter irritation, which relieves the pain as well as itching associated with the scab base. And due to the volatile nature of this drug, when it is going to be applied on the skin, it is easily evaporated, resulting in the cooling effect.
So this drug can produce both countering retained action as well as cooling effect, which reduce the itching, thereby it can increase the comfort in the pruritis conditions. And since this drug acts as a counter retardant, if it is applied on the normal skin, again, it can produce the itching and pruritis. This cream is not meant for ophthalmic purpose. When this drug is accidentally applied on the eye, it can produce the irritation, resulting in the redness of the eye. Similarly, this drug is not indicated for oral purpose.
This drug is available as a lotion as well as cream. Both forms can be used. In the step one, this drug should be applied on the entire body area. So this drug can be applied from the chin to the toe, on the affected areas so that it can reduce the itching response. Even it can be applied on the nail beds where the scab ismites can be present.
So this motion should be applied on the nail tips in order to produce scabicidal action. And the motion can be further applied after 24 hours based on the effectiveness. So a second application can be done in the step two, again, on the entire body except the eye and mouth.
This motion should be thoroughly applied on the folding of the skin. Thereby, it can produce effective treatment for the scab base. After 48 hours, this motion should be thoroughly cleaned on the skin to prevent any dryness and irritation of the skin. In this way, either the motion or creme can be applied.
And it is applied in two doses with a gap of 24 hours. And after 48 hours of last application, this lotion or cream should be removed from the skin in order to reduce the skin irritation. Now, let us the chemical nature of this type. So this is the structure of cr otamate on. Here we can observe the amide. So let us give the numbering.
This is 1, 2, 3, 4. So this is the amide formed by crotonic acid. And we can write this as 2 butane amide. Now, to the nitrogen, one of the group is the ethyl so N ethyl. And second group is the N dash 2 Methyl Phenyl. That is the complete name of Crutamate O n. Now, let us see how this drug acts. Even the exact mechanism is not known, Histamine plays an important role in the itching response.
It can act on the noxceptive neurons which are equipped with H 1 receptors. Again, these neurons are also equipped with TRPV1 channels, which are the vanilla receptor so that they can produce excitation of the neurons. Now, when Histamine acts on the H 1 receptor, they are activated so that they can further sensitize the TRPV1 channels.
Then calcium can enter through the TRPV1 channels, resulting in the excitation and depolarisation of the neurons. So this produced the itching response. And even the itching response can also be increased by other type of channels, TRPV4 channels. These are the channels which are sensitized by heat. So calcium can more enter through these channels, again, produce itching and wariness of the skin. Now, quratamitan is one of the counter irritant which can inhibit the H 1 receptor.
It can also block the TRP1 activity as well as TRPV4 activity. Even the exact mechanism is not clear, but any of these actions may result in decreased neuronal excitation and itching response. What are the precautions? One of the important precaution of clotamidin is that this drug can produce some skin irritation. As a counter irritant, this type can produce some allergic response, resulting in skin rashes, dermatitis, even pruritis conditions can be produced by clotamidone.
This drug should not be applied on the eye. When it is going to be applied on the eye, it can produce skin irritation. This drug should not be in contact with the eye, mouth, nose, and Vesena. Similarly, this drug should be carefully given in the pregnant women as the safety is not completely established. What are the side effects?
The important side effects are the local reactions. It can produce skin rashes, skin irritation, some pruritis, warm sensation, and allergic reactions can be produced by this drug. How it is given? This drug is available in two dosage forms. It is available as a lotion as well as cream at a strength of 10 %. So when it is going to be applied on the skin at two applications separated by 24 hours, it can reduce the scabies and pruritic conditions.
So that’s about this drug, Crutamate O ns, which is a scabicidal and anti p ruritic drug, and it is a crotonic acid amyte derivative. This drug is applied topically either by cream or motion to reduce the itching and e exhema. Skin irritation is one of the important side effect that is produced by this drug and it should not be applied to the eye, mouth, or the vagina where it can produce some severe irritation.
