Halobetasol propionate ointment let us discuss HelloBetaSol Propionate. What is this drug? Hellobetasol? The suffix sol indicates that this drug is one of the topical corticosteroids. This drug is available in the ester form as propionate. So Hello Betasol propionate is one of the topical corticosteroids. Among the corticosteroids, we have different types of drugs which are classified as highly potent.
medium potent and mild potent. But Hello Betasol propionate is classified as super potent steroid. So this drug is very potent, that’s why it is not indicated for the children. In the adults with age greater than 18 years only, this HelloBit Salpropionate is used as topical corticosteroid. So any exposure of this drug to the children produce systemic toxity. That’s why its contact should be completely avoided with the children.
And this drug is indicated for the treatment of plaque psoriasis, where it can produce anti Inferiori effect. Thereby, it can reduce the plaque formation. And this drug is available in different dosage forms as ointment, cream, even it is available as a lotion as well as foam. All these are intended for topical purpose and they should be applied on the affected area on the skin, but they should not be applied to the eye because on the eye, HelloBedSol can produce few of the ophthalic side effects.
Being a corticosteroid, this drug can increase the risk of glaucoma and cataracts. That’s why this drug should not be applied to the eye. Similarly, this drug should not be applied to the groin area, axillary, under arms, as this drug further increase the skin irritation and local reactions. So this drug is mainly indicated for p lexoriasis by topical route in the adults with age greater than 18 years. Now, let us see the precautions of this drug. One of the important precaution is that HelloBitSol is indicated for topical purpose.
But when this drug is applied topically, fear of drug molecules may enter into the systemic circulation. So this systemic absorption may suppress the HP axis, hypothalamus pituitary adrenal axis. By suppression of this axis, the cortisol is somewhat less released from the adrenal glands, which results in the symptoms such as Cushing syndrome. So by separation of HP axis, we can observe the symptoms of Cushing syndrome in the patients.
The patient may have increased weight gain. Some reddening of the face can be observed. Blood pressure may be increased, resulting in the hypertension. Blood sugar levels are increased, resulting in the hyperglycemia. Even glucose is more excreted within the urine, resulting in the glucose urea.
All these symptoms can be observed by separation of HP axis. That’s why the systemic exposure of this drug should be minimized, which can be achieved by for short term use of this drug. So HelloBetsol propionate should be used only for two weeks. When it is used for more than two weeks, it can increase the systemic exposure, resulting in the separation of HP axis.
And the important precaution is that this drug should be applied on the skin, but it should not be covered with occlusive dressings. So bandages and occlusive dressing should not be applied as they further increase the contact with the skin, which increase the systemic absorption. So generally, HelloBedSol propionate should be applied on the intact skin.
Similarly, this truck can produce some local skin reactions, resulting in various symptoms such as skin irritation, stra f formation, skin atrophy, thinning of the skin, even acne type eruptions, hypopigmentation, all these are possible with the HelloBetsol propionate. Now, let us see the side effects of this drug.
all mainly produce local skin reactions. It can produce some headache, dryness of the skin, skin atrophy, thinning of the skin, burning sensation, skin irritation, widening of small blood vessels, which is more important when this drug is applied frequently for two weeks, which resists in the thinning of the skin, and it can also produce some stinging sensation, and finally, it can produce some contact dermatitis.
Now, let us see how this drug acts. Hellobitol propionate can act on the glucocortic acid receptors. These glucocortic receptors are present within the cytoplasm. They are coupled with one of the protein HSP90, heat shock protein 90. Now, when Hellobitol binds to these glucocortic receptors, this heat shock protein is removed and glucocortica receptors are internalized where they can undergo dimerization.
So after dimerization, they can produce gene transcription, resulting in the production of mRNA. Now, this mRNA can guide the protein sensors at the ribosome, where the proteins are going to be synthesized, such as Lipocortin 1 and anexin A1. These are the proteins which can reduce the inflammatory cascade.
Thereby, they can reduce inflammation within the cells. Similarly, if you have the inflammatory mediators can act on these cells. When they bind to their corresponding receptors, they can activate one of the pathway, NFFKB, nuclear factor KappaB. Now, this nuclear factor KappaB can again interact with the DNA, where it can produce gene transcription, resulting in the release of various inflammatory mediators. These mediators can produce inflammation, which is again controlled by hall of Bayley sol propionate. Now, this Halobuticil propionate can inhibit the NFKB pathway so that you can reduce the release of inflammatory mediators.
Even this drug can reduce release of Prostaglandines by increase the activity of NXA1. This nxin A1 can inhibit the activity of fast polypase A2. Thereby, it can inhibit the release of Prostaglandines. By all these actions, hall of Betisol propionatecan reduce the inflammatory response. How it is given? This drug is available as ointment, lotion, as well as foam. All these are available at a strength of 0.05 %.
At this concentration, this drug should be applied twice daily on the affected area. But the treatment should be continued up to two weeks. For more than two weeks, this drug is not recommended as it can suppress the HP axis. That’s about this drug, Halobate salt propionate, which is a topical corticosteroid indicator for the treatment of p lexoriasis.
Being a super potent corticosteroid, this drug should be used in the adults with age greater than 18 years. This drug should be applied twice daily for maximum two weeks. The weekly dose should be less than 50 gram in order to minimize the systemic exposure. This drug can produce suppression of HP axis by systemic absorption, which can produce a symptom such as Cushing syndrome. With that precaution, this drug can be applied topically for the treatment of p lexoriasis.
